This episode features Matthew Baggott of Tactogen Inc. and will explore entactogens, which are drugs like MDMA, 2C-B, and Methalone.

We start with setting a basic framework for what an entactogen is and a few example drugs, before exploring the complexities in their various effects, mechanisms of action, and both the legislative and technical process of the development of novel or new entactogenic drugs.

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For links to Baggott's work, full show notes, and a link to watch this episode in video, head to bit.ly/ATTMind177

*** FULL TOPICS BREAKDOWN BELOW**

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Episode Breakdown

• (0:00 ) Opening
• (2:44 ) Guest Bio
• (4:06 ) Patreon thanks | Support The Show
• (5:42 ) Interview begins
• (6:31 ) What is an entactogen and what does it do? | The difference between entactogens and psychedelics
• (8:37 ) A short discussion about 2C-B
• (11:47 ) A list of different entactogens
• (15:30 ) r-MDMA vs s-MDMA
• (19:48 ) Methalone, aka bk-MDMA
• (21:52 ) 3-MMC and 4-MMC: patents, development, and legality
• (23:13 ) Why Schedule 1 makes drug development difficult
• (25:02 ) The qualities they are trying to design OUT of new entactogen drugs (pt1)
• (26:31 ) “The loss of magic” with MDMA
• (33:11 ) Serotin transporters and MDMA neuro-oxidization
• (36:27 ) Using NAC to bring back the MDMA magic | enhanced plasticity, antioxidants, and homeostasis
• (44:13 ) The qualities they are trying to design OUT of new entactogen drugs (pt2)
• (48:52 ) Why we need “take home” entactogenic drugs
• (53:20 ) Can a drug still be medicine if it’s fun, too?
• (58:13 ) The process of justifying off-label MDMA prescriptions
• (1:03:01 ) Will there be a moral backlash against the development of “good feel” drugs?
• (1:11:10 ) The negative social consequences of prohibitionist law enforcement
• (1:15:58 ) We can’t just give people psychedelics and expect society will get better
• (1:18:46 ) Problematic moves in the psychedelic biotech industry
• (1:25:01 ) Psychedelic Patent Trolling
• (1:32:15 ) How Tactogen is trying to give back to psychedelic users
• (1:44:16 ) Increasing access to health care, not just to psychedelic substances
• (1:49:40 ) Follow-up link and contact details
• (1:51:25 ) closing